Incretin secretion stimulated by ursodeoxycholic acid in healthy subjects
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چکیده
منابع مشابه
Incretin secretion stimulated by ursodeoxycholic acid in healthy subjects
Bile acids play an important role in post-prandial glucose metabolism by stimulating release of glucagon-like peptide-1 (GLP-1) via the G-protein-coupled receptor TGR5, which is expressed in intestinal L cells. Thus, bile acid sequestrants are expected to stimulate secretion of endogenous GLP-1 through TGR5. We investigated incretin and insulin secretion after a meal with and without ursodeoxyc...
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BACKGROUND/AIMS Ursodeoxycholic acid (UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones. It remains unclear whether these changes in biliary cholesterol excretion are associated with changes in cholesterol synthesis and bile acid synthesis. We therefore studied the activities of rate-limiting enzymes of cholesterol synthesis and...
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ژورنال
عنوان ژورنال: SpringerPlus
سال: 2013
ISSN: 2193-1801
DOI: 10.1186/2193-1801-2-20